Hemostasis changes in patients with Covid-19 (Literature review)

Ecaterina Maniuc; Serghei Sandru; Tatiana Ambrosii; Andrei Vilijinschii; Oleg Tarabrin; Jana Bernic; Eva Gudumac

doi:10.52673/18570461.26.1-80.07

Autori

Ecaterina Maniuc Institutul Mamei şi Copiluluii https://orcid.org/0000-0002-8548-4467
Serghei Şandru Institutul de Medicină Urgentă https://orcid.org/0000-0002-2973-9154
Tatiana Ambrosii Institutul de Medicină Urgentă https://orcid.org/0000-0002-7467-8821
Andrei Vilijînschii Institutul de Medicină Urgentă
Oleg Tarabrin International Humanitarian University https://orcid.org/0000-0002-1649-5955
Jana Bernic Universitatea de Medicină și Farmacie Nicolae Testemițanu din Chișinău https://orcid.org/0000-0001-6991-9814
Eva Gudumac Institutul Mamei şi Copiluluii https://orcid.org/0000-0001-8474-4338

DOI:

https://doi.org/10.52673/18570461.26.1-80.07

Cuvinte cheie:

sistemul complementului, COVID-19, D-dimer, celule endoteliale, hemostază, macrofage, tromboză

Rezumat

În anul 2020, pandemia globală de COVID-19, cauzată de coronavirusul SARS-CoV-2, a constituit o provocare majoră pentru sistemele de sănătate la nivel mondial. O caracteristică importantă a acestui virus este tendința sa de a afecta endoteliul vaselor de sânge, determinând apariția endoteliitei și o serie de anomalii ale sistemului de coagulare a sângelui, inclusiv coagulopatii cu formare crescută de trombină, creșterea D-dimerului, scăderea fibrinolizei și prelungirea timpului de protrombină. Aceste dereglări ale sistemului de coagulare a sângelui reprezintă un aspect-cheie al patogenezei hipercoagulabilității în COVID-19. Hipercoagulabilitatea în acest context este însoțită de niveluri ridicate ale factorului von Willebrand, ale factorului VIII, formarea de capcane extracelulare neutrofile și activarea trombocitelor.

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